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Article

HAP40 is a conserved central regulator of Huntingtin and a specific modulator of mutant Huntingtin toxicity

2020-05-30

Abstract excerpt

Perturbation of Huntingtin (HTT)’s physiological function is one postulated pathogenic factor in Huntington’s disease (HD). However, little is known how HTT is regulated in vivo . In a proteomic study, we isolated a novel ∼40kDa protein as a strong binding partner of Drosophila HTT and demonstrated it was the functional ortholog of HAP40, an HTT associated protein shown recently to modulate HTT’s conformation bu...

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Literature Corpus work
69267a7c-434d-5b81-9133-b74055129345
DOI
10.1101/2020.05.27.119552
Open publication

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HAP40 is a conserved central regulator of Huntingtin and a specific modulator of mutant Huntingtin toxicityDOI 10.1101/2020.05.27.119552
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