Article

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity

2020-07-11

Abstract excerpt

Protein dimerization systems that can be controlled by red light with increased tissue penetration depth are a highly needed optogenetic tool for clinical applications such as cell and gene therapies. However, existing red light-induced dimerization systems are all based on phytochrome photoreceptors and naturally occurring binding partners with complex structures and suboptimal in vivo performance, limiting mamm...

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Literature Corpus work: 6798ea4c-ee4e-582a-8758-62eed8ca58fd
DOI: 10.1101/2020.07.09.174003

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