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Article

Light-controlled gene switches in mammalian cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Zhang Fuzhong, Müller Kristian M, Woolley G Andrew, Arndt Katja M

Abstract excerpt

Remote control of cells is a desirable feature in synthetic biology. We established a light-switchable interfering peptide (iPEP) which controls gene expression by modulating the activity of a transcription factor. For photo-switching, the iPEP is cross-linked with a cis-trans isomerizable cross-linker in such a way that the light-activated cis form enables inhibitor folding rendering it active, whereas the...

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PMID: 22083744
DOI: 10.1007/978-1-61779-412-4_12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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