Article

Regulatable In Vivo Gene Expression via Adaptamers

2025-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Precise, reversible control of transgene expression is essential for safe and durable gene therapy, yet current inducible systems remain difficult to translate in vivo due to large size, limited induction duration, and dependence on immunogenic regulators. Here we present the adaptamer ( AD AR modulatable aptamer ), a compact (<120 bp) RNA switch that couples an FDA-approved small-molecule–re...

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Literature Corpus work: 1e69c51e-44db-562e-8880-c8ff52cbb6af
DOI: 10.64898/2025.12.21.695777

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