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Article

A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription.

ACS chemical biology - 16 Feb 2018

Zhou Xin X, Zou Xinzhi, Chung Hokyung K, Gao Yuchen, Liu Yanxia, Qi Lei S, Lin Michael Z

Abstract excerpt

Optical control of CRISPR-Cas9-derived proteins would be useful for restricting gene editing or transcriptional regulation to desired times and places. Optical control of Cas9 functions has been achieved with photouncageable unnatural amino acids or by using light-induced protein interactions to reconstitute Cas9-mediated functions from two polypeptides. However, these methods have only been applied to one Cas9...

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Identifiers

PMID: 28938067
DOI: 10.1021/acschembio.7b00603
PMCID: PMC5820652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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