Article

Striatal Circuit Development and Its Alterations in Huntington’s Disease

2020-05-31

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder that usually starts during midlife with progressive alterations of motor and cognitive functions. The disease is caused by a CAG repeat expansion within the huntingtin gene leading to severe striatal neurodegeneration. Recent studies conducted on pre-HD children highlight early striatal developmental alterations starting as soon as 6 years old, t...

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Literature Corpus work: 08817184-6170-5424-9553-0a56dfe56cb9
DOI: 10.20944/preprints202005.0488.v1

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