Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease

5 Dec 2024

Abstract excerpt

There is a growing consensus that brain development in Huntington's disease (HD) is abnormal, leading to the idea that HD is not only a neurodegenerative but also a neurodevelopmental disorder. Indeed, structural and functional abnormalities have been observed during brain development in both humans and animal models of HD. However, a concurrent study of cortical and striatal development in a genetic model of HD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39644979
DOI: 10.1016/j.nbd.2024.106752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's diseasePMID 39644979Read ↗

Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington’s DiseaseSemantic proximity Read ↗

Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington’s diseaseSemantic proximity Read ↗

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.Semantic proximity Read ↗

Synaptic Dysfunction in Huntington’s Disease: Lessons from Genetic Animal ModelsSemantic proximity Read ↗

Late onset of striatal projection neuron hyperexcitability in <i>Fmr1</i> -/y miceSemantic proximity Read ↗

Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's DiseaseSemantic proximity Read ↗

Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of neonatal and juvenile <i>STXBP1</i> heterozygous miceSemantic proximity Read ↗

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington’s DiseaseSemantic proximity Read ↗

Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington DiseaseSemantic proximity Read ↗

Alterations in Striatal Synaptic Transmission are Consistent across Genetic Mouse Models of Huntington’s DiseaseSemantic proximity Read ↗

Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophreniaSemantic proximity Read ↗

Genetic Mouse Models of Huntington’s Disease: Focus on Electrophysiological MechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.