Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's Disease

11 Mar 2015

Abstract excerpt

Abnormal electrophysiological activity in the striatum, which receives dense innervation from the cerebral cortex, is believed to set the stage for the behavioral phenotype observed in Huntington's disease (HD), a neurodegenerative condition caused by mutation of the huntingtin (mhtt) protein. However, cortical involvement is far from clear. To determine whether abnormal striatal processing can be explained by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25762686
DOI: 10.1523/jneurosci.2812-14.2015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's DiseasePMID 25762686Read ↗

Genetic Mouse Models of Huntington’s Disease: Focus on Electrophysiological MechanismsSemantic proximity Read ↗

Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington’s diseaseSemantic proximity Read ↗

Synaptic Dysfunction in Huntington’s Disease: Lessons from Genetic Animal ModelsSemantic proximity Read ↗

Restoring cortical disinhibition improves Huntington's disease phenotypes.Semantic proximity Read ↗

Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathwaySemantic proximity Read ↗

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.Semantic proximity Read ↗

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and SurvivalSemantic proximity Read ↗

Early alterations of motor learning and corticostriatal network activity in a Huntington’s disease mouse modelSemantic proximity Read ↗

Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington’s diseaseSemantic proximity Read ↗

Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington DiseaseSemantic proximity Read ↗

A novel key player in cognitive striatal processes: the Pthlh interneuronsSemantic proximity Read ↗

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington’s Disease Mouse StriatumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.