Article

Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington’s disease

2024-05-10

Abstract excerpt

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene encoding the Huntingtin protein (Htt). While symptoms, primarily characterized by progressive deterioration of the striatum and motor and cognitive functions, typically manifest in adulthood, recent studies have also highlighted developmental defects in HD. Indeed, alterations in cortical and striatal development...

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Literature Corpus work: 6fb619ef-6729-5c47-aacc-0629c8d83992
DOI: 10.1101/2024.05.10.593545

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