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Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway

27 Nov 2021

Abstract excerpt

Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of striatal projection neurons and less but significant loss in other areas throughout the cortico-basal ganglia-thalamocortical (CBGTC) loop. The mutant huntingtin protein...

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PMID: 34848336
DOI: 10.1016/j.nbd.2021.105574

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