Article

Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington’s Disease

2024-10-18

Abstract excerpt

There is a growing consensus that brain development in Huntington’s disease (HD) is abnormal, leading to the idea that HD is not only a neurodegenerative but also a neurodevelopmental disorder. Indeed, structural and functional abnormalities have been observed during brain development in both humans and animal models of HD. However, a concurrent study of cortical and striatal development in a genetic model of HD i...

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Literature Corpus work: f53c956d-5fcc-5f47-96a6-a579e667d07c
DOI: 10.1101/2024.10.15.618500

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