Article

DNA Methylation in the Pathogenesis of Systemic Lupus Erythematosus.

2005-03-01

Abstract excerpt

Some forms of drug-induced lupus may be due to inhibition of T cell DNA methylation. DNA methylation modifies gene expression. In general, methylation of regulatory elements suppresses gene expression, while hypomethylation promotes gene expression. Methylation patterns are replicated during mitosis by a family of DNA methyltransferases, whose expression is regulated in part by signals transmitted through the extr...

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Literature Corpus work: 08541b0c-cb92-5d8f-9bee-03268532488a
DOI: 10.2174/1570160053174983

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