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Article

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases.

Trends in molecular medicine - 1 Dec 2011

Hedrich Christian M, Tsokos George C

Abstract excerpt

The pathogenic origin of autoimmune diseases can be traced to both genetic susceptibility and epigenetic modifications arising from exposure to the environment. Epigenetic modifications influence gene expression and alter cellular functions without modifying the genomic sequence. CpG-DNA methylation, histone tail modifications and microRNAs (miRNAs) are the main epigenetic mechanisms of gene regulation....

Topics

Animals
Chromatin
DNA Methylation
Environmental Exposure
Epigenesis, Genetic
Gene Expression Regulation
Genetic Predisposition to Disease
Histones
Humans
Lupus Erythematosus, Systemic
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MicroRNAs

Nucleosomes

Protein Processing, Post-Translational

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 21885342
DOI: 10.1016/j.molmed.2011.07.005
PMCID: PMC3225699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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