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Article

The Epigenetic Face of Systemic Lupus Erythematosus

1 Jun 2006

Abstract excerpt

Systemic lupus erythematosus (SLE) is an archetypical systemic, autoimmune inflammatory disease characterized by the production of autoantibodies to multiple nuclear Ags. Apoptotic defects and impaired removal of apoptotic cells contribute to an overload of autoantigens that become available to initiate an autoimmune response. Besides the well-recognized genetic susceptibility to SLE, epigenetic factors are...

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PMID: 16751355
DOI: 10.4049/jimmunol.176.12.7143

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