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Article

Epigenetic regulation and the pathogenesis of systemic lupus erythematosus.

Translational research : the journal of laboratory and clinical medicine - 1 Jan 2009

Pan Yujun, Sawalha Amr H

Abstract excerpt

The pathogenesis of systemic lupus erythematosus (SLE) is incompletely understood. Studies in both lupus animal models and human disease indicate a clear role for epigenetic defects, particularly DNA methylation, in the pathogenesis of lupus. T-cell DNA from active lupus patients is hypomethylated, which results in overexpression of methylation-regulated genes, T-cell autoreactivity, and autoimmunity in vivo....

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Topics

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Share to Chromosomes, Human, X
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Histones

Share to Lupus Erythematosus, Systemic

Share to Methyl-CpG-Binding Protein 2

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Source

Identifiers

PMID: 19100952
DOI: 10.1016/j.trsl.2008.10.007

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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