Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reconciling Non-Genetic Plasticity with Somatic Evolution in Cancer.

Trends in cancer - 1 Apr 2021

Huang Sui

Abstract excerpt

Post-treatment progression of tumors is commonly explained by somatic Darwinian evolution (i.e., selection of cells carrying genetic mutations that create more aggressive cell traits). But cancer genome and transcriptome analyses now paint a picture far more complex, prompting us to see beyond the Darwinian scheme: non-genetic cell phenotype plasticity explained by alternative stable gene expression states...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Disease Progression
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Source

Identifiers

PMID: 33536158
DOI: 10.1016/j.trecan.2020.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reconciling Non-Genetic Plasticity with Somatic Evolution in Cancer.PMID 33536158Read ↗

The many faces of cancer evolutionSemantic proximity Read ↗

Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me'.Semantic proximity Read ↗

Cancer plasticity: Investigating the causes for this agilitySemantic proximity Read ↗

Cancer as a reprogramming-like disease: Implications in tumor development and treatmentSemantic proximity Read ↗

SnapShot: Tumor evolution.Semantic proximity Read ↗

Tumor Evolution Is Directed by Cellular Responses to Survival ChallengesSemantic proximity Read ↗

Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity.Semantic proximity Read ↗

Cancer evolution: from Darwin to the Extended Evolutionary SynthesisSemantic proximity Read ↗

Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer.Semantic proximity Read ↗

A Non-Genetic Basis for Cancer Progression and Metastasis: Self-Organizing Attractors in Cell Regulatory NetworksSemantic proximity Read ↗

Cancer: More than a geneticist's Pandora's box.Semantic proximity Read ↗

Phenotypic noise and plasticity in cancer evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.