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Article

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

4 May 2023

Abstract excerpt

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors remain poorly defined. We now document spontaneous and reversible plasticity between the two identities, associated with epigenetic reprogramming, in several neuroblastoma...

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PMID: 37142597
DOI: 10.1038/s41467-023-38239-5

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