Article

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

2020-05-05

Abstract excerpt

Neuroblastoma is a heterogeneous embryonal malignancy and the most deadly tumor of childhood, although a minor subset may show spontaneous differentiation. It arises from the multipotent neural crest lineage during development. Some of this multipotency is retained in neuroblastoma, which can give rise to both adrenergic and mesenchymal tumor cells. The mechanisms enabling such dual fates are unknown, but likely h...

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Literature Corpus work: c8776c9b-0d37-5ca9-a7fe-7b8d827f9720
DOI: 10.1101/2020.05.04.077057

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