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The molecular determinants of phenotypic plasticity in homeostasis and neoplasia

13 Dec 2024

Abstract excerpt

Phenotypic plasticity, the capacity of cells to transition between distinct phenotypic and lineage states over time, is a genetically and epigenetically encoded trait essential for normal development and adult tissue homeostasis. In cancer, phenotypic plasticity programs can be deployed aberrantly to enable disease progression and acquired therapeutic resistance. Cancer phenotypic plasticity is a current barrier...

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Histone Deacetylase Inhibitors Research
PARP inhibition in cancer therapy
Protein Degradation and Inhibitors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40994652
DOI: 10.47248/chp2401020010

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