Article
Roadmap on plasticity and epigenetics in cancer.
Physical biology - 18 Apr 2022
Foo Jasmine, Basanta David, Rockne Russell C, Strelez Carly, Shah Curran, Ghaffarian Kimya, Mumenthaler Shannon M, Mitchell Kelly, Lathia Justin D, Frankhouser David, Branciamore Sergio, Kuo Ya-Huei, Marcucci Guido, Velde Robert Vander, Marusyk Andriy, Huang Sui, Hari Kishore, Jolly Mohit Kumar, Hatzikirou Haralampos, Poels Kamrine E, Spilker Mary E, Shtylla Blerta, Robertson-Tessi Mark, Anderson Alexander R A
Abstract excerpt
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that...
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