Phenotypic noise and plasticity in cancer evolution.

Abstract excerpt

Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these phenomena can influence a cell's fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions of 'phenotypic plasticity' in cancer evolution ignore a salient feature of the original definition: namely, that it occurs in response to an environmental change. We suggest 'phenotypic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Plasticity
• Share to Evolution, Molecular
• Share to Neoplasms