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VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

2023-01-07

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Cholesteryl ester (CE) accumulation in intracellular lipid droplets (LDs) is an essential signature of clear cell renal cell carcinoma (ccRCC), but its molecular mechanism and pathological significance remain elusive. <h4>Methods</h4> Enabled by the label-free Raman spectromicroscopy, which integrated stimulated Raman scattering microscopy with confocal Raman spectroscopy on...

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Literature Corpus work: 0802df26-cb40-5273-a005-98e484a242d4
DOI: 10.1101/2023.01.02.522447

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