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Article

Increased expression of CD36 and CD163 in clear cell renal cell carcinoma suggests an association between lipid transport and an "M2-like" macrophage phenotype.

Frontiers in immunology - 1 Jan 2026

Bouraoui Yosra, Said Rahma, Bruss Christina, Martowicz Agnieszka, Wagner Kilian, Weber Florian, Engelmann Simon U, Kaelble Sebastian, Höring Marcus, Liebisch Gerhard, Mayr Roman, Siska Peter J

Abstract excerpt

Background: Clear cell renal cell carcinoma (ccRCC) is marked by intracellular lipid accumulation and dysregulated lipid metabolism, features that contribute to tumor progression and possibly immune suppression. Tumor-associated macrophages (TAMs) in ccRCC are abundant and phenotypically diverse, with CD68 marking general macrophage presence and CD163 indicating alternatively activated, immunosuppressive...

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Share to Antigens, Differentiation, Myelomonocytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to CD163 Antigen

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Share to Kidney Neoplasms

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Source

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Identifiers

PMID: 41846920
DOI: 10.3389/fimmu.2026.1773666
PMCID: PMC12989337

Genes

CD163
CD36
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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