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Article

VHL mutation drives human clear cell renal cell carcinoma progression through PI3K/AKT-dependent cholesteryl ester accumulation.

EBioMedicine - 1 May 2024

Zhang Shuo, Fang Tinghe, He Yexuan, Feng Weichen, Yu Zhuoyang, Zheng Yaoyao, Zhang Chi, Hu Shuai, Liu Zhuojun, Liu Jia, Yu Jian, Zhang Han, He Anbang, Gong Yanqing, He Zhisong, Yang Kaiwei, Xi Zhijun, Yu Wei, Zhou Liqun, Yao Lin, Yue Shuhua

Abstract excerpt

BACKGROUND: Cholesteryl ester (CE) accumulation in intracellular lipid droplets (LDs) is an essential signature of clear cell renal cell carcinoma (ccRCC), but its molecular mechanism and pathological significance remain elusive. METHODS: Enabled by the label-free Raman spectromicroscopy, which integrated stimulated Raman scattering microscopy with confocal Raman spectroscopy on the same platform, we...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Identifiers

PMID: 38564827
DOI: 10.1016/j.ebiom.2024.105070
PMCID: PMC10999658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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