Back to search

Article

MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal Carcinoma

2019-05-23

Abstract excerpt

The most common kidney cancer, clear cell Renal Cell Carcinoma (ccRCC) is closely associated with obesity. In fact, the “clear cell” variant of RCC is given this name due to large lipid droplets within the tumor cells. Although it is well appreciated that renal lipid metabolism is altered in ccRCC, the mechanisms driving this are not well understood. Leveraging a shotgun lipidomics approach we have identified a li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dcfa1782-2daf-5e93-894a-6040efa0e78e
DOI
10.1101/648378
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal CarcinomaDOI 10.1101/648378
A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysisSemantic proximity
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progressionSemantic proximity
Integrative analysis of bulk and single-cell RNA sequencing reveals sphingolipid metabolism and immune landscape in clear cell renal cell carcinoma.Semantic proximity
Cardiolipin remodeling reflects mitochondrial reprogramming in clear cell renal cell carcinomaSemantic proximity
The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinomaSemantic proximity
The Multi-Omics Analyses of ACSL1 Reveal Its Translational Significance as a Tumor Microenvironmental and Prognostic Biomarker in Clear Cell Renal Cell CarcinomaSemantic proximity
Increased expression of CD36 and CD163 in clear cell renal cell carcinoma suggests an association between lipid transport and an "M2-like" macrophage phenotype.Semantic proximity
Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma.Semantic proximity
High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell CarcinomaSemantic proximity
Lipid in Renal Carcinoma: Queen Bee to Target?Semantic proximity
MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2Semantic proximity
Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.