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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression

15 Feb 2024

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our analysis identifies four ccRCC subtypes including De-clear cell differentiated (DCCD)-ccRCC, a subtype with...

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PMID: 38361033
DOI: 10.1038/s41588-024-01662-5

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