Article
VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling.
Journal of experimental & clinical cancer research : CR - 8 Jun 2020
Sun Jinbo, Tang Qisheng, Gao Yongheng, Zhang Wei, Zhao Zhining, Yang Fan, Hu Xiangnan, Zhang Dan, Wang Yong, Zhang Huizhong, Song Bin, Zhang Bo, Wang He
Abstract excerpt
BACKGROUND: Although ongoing development of therapeutic strategies contributes to the improvements in clinical management, clear cell renal cell carcinoma (ccRCC) deaths originate mainly from radiochemoresistant and metastatic disease. Transcription factor SALL4 has been implicated in tumorigenesis and metastasis of multiple cancers. However, it is not known whether SALL4 is involved in the pathogenesis of ccRCC....
Topics
- Animals
- Apoptosis
- Biomarkers, Tumor
- Carcinoma, Renal Cell
- Cell Proliferation
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Glycogen Synthase Kinase 3 beta