Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid in Renal Carcinoma: Queen Bee to Target?

Trends in cancer - 1 Jun 2020

Tan Sze Kiat, Welford Scott M

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell
Share to Carnitine O-Palmitoyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Lipid Droplets

Share to Peroxisomes

Share to Proteolysis

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 32459999
DOI: 10.1016/j.trecan.2020.02.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid in Renal Carcinoma: Queen Bee to Target?PMID 32459999Read ↗

Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinomaSemantic proximity Read ↗

The Multi-Omics Analyses of ACSL1 Reveal Its Translational Significance as a Tumor Microenvironmental and Prognostic Biomarker in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

A cluster of metabolism-related genes predict prognosis and progression of clear cell renal cell carcinomaSemantic proximity Read ↗

A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysisSemantic proximity Read ↗

The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinomaSemantic proximity Read ↗

Cardiolipin remodeling reflects mitochondrial reprogramming in clear cell renal cell carcinomaSemantic proximity Read ↗

MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal CarcinomaSemantic proximity Read ↗

miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathwaySemantic proximity Read ↗

High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

The prospect of precision therapy for renal cell carcinoma.Semantic proximity Read ↗

BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinomaSemantic proximity Read ↗

Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.