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Integrative analysis of bulk and single-cell RNA sequencing reveals sphingolipid metabolism and immune landscape in clear cell renal cell carcinoma.

Environmental toxicology - 1 Dec 2024

Xie Dongdong, Han Zhitao, Wang Yu, Shi Haoyu, Wu Xiang, Wu Jiaqing, Dai Yingbo

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive behavior and complex molecular heterogeneity, posing significant challenges for treatment and prognostication. This study offers a comprehensive analysis of ccRCC by leveraging both bulk and single-cell RNA sequencing data, with a specific aim to unravel the complexities of sphingolipid metabolism and the intricate dynamics within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39230203
DOI: 10.1002/tox.24319

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