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Article

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.

Genomics, proteomics & bioinformatics - 1 Aug 2022

Zhu Songbiao, Ding Wenxi, Chen Yuling, Wang Weixuan, Xu Renhua, Liu Chongdong, Liu Xiaohui, Deng Haiteng

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a frequently occurring renal cancer. The Von Hippel-Lindau disease tumor suppressor VHL, a known tumor suppressor gene, is frequently mutated in about 50% of patients with ccRCC. However, it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL. In the present study, we found that higher expression of VHL was correlated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33647481
DOI: 10.1016/j.gpb.2019.12.002
PMCID: PMC9880812

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