Article

A novel brainstem pathway to the circadian system links Tau neurofibrillary pathology to sundowning-related circadian dysfunction and associated sex differences in the TAPP mouse model of Alzheimer’s disease

2022-12-19

Abstract excerpt

Patients with Alzheimer’s disease (AD) exhibit a progressive disruption of entrained circadian rhythms that first appears long before cognitive symptoms develop. Additionally, work combining analyses of actigraphy and hypothalamic tissue from AD patients suggests that an input to the circadian system may underlie such dysfunction, rather than the presence of pathology and neurodegeneration in the master circadian...

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Literature Corpus work: 079a27f0-d32f-5815-82f0-1342656f84d4
DOI: 10.21203/rs.3.rs-2375300/v1

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A novel brainstem pathway to the circadian system links Tau neurofibrillary pathology to sundowning-related circadian dysfunction and associated sex differences in the TAPP mouse model of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-2375300/v1Read

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