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Article

Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice.

Current Alzheimer research - 1 Jan 2017

Oyegbami Olaide, Collins Hilary M, Pardon Marie-Christine, Ebling Francis J P, Heery David M, Moran Paula M

Abstract excerpt

BACKGROUND: In addition to cognitive decline, Alzheimer's Disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or night and have been referred to as 'sundowning'. They are especially difficult for carers and there are no specific drug treatments. There is increasing evidence that these symptoms reflect pathology of circadian rhythm...

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PMID: 28317486
DOI: 10.2174/1567205014666170317113159

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