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Article

Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL-F/NL-F Models of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Britz Jesse, Ojo Emmanuel, Dhukhwa Asmita, Saito Takashi, Saido Takaomi C, Hascup Erin R, Hascup Kevin N, Tischkau Shelley A

Abstract excerpt

BACKGROUND: Circadian disruption has long been recognized as a symptom of Alzheimer's disease (AD); however, emerging data suggests that circadian dysfunction occurs early on in disease development, potentially preceding any noticeable cognitive deficits. OBJECTIVE: This study compares the onset of AD in male and female wild type (C57BL6/J), transgenic (AβPP/PS1), and knock-in (APPNL-F/NL-F) AD mouse models from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34897085
DOI: 10.3233/JAD-210629
PMCID: PMC8900657

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