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Article

Disruption of normal circadian clock function in a mouse model of tauopathy.

Experimental neurology - 1 Aug 2017

Stevanovic Korey, Yunus Amara, Joly-Amado Aurelie, Gordon Marcia, Morgan David, Gulick Danielle, Gamsby Joshua

Abstract excerpt

Disruption of normal circadian rhythm physiology is associated with neurodegenerative disease, which can lead to symptoms such as altered sleep cycles. In Alzheimer's disease (AD), circadian dysfunction has been attributed to β-amyloidosis. However, it is unclear whether tauopathy, another AD-associated neuropathology, can disrupt the circadian clock. We have evaluated the status of the circadian clock in a mouse...

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Identifiers

PMID: 28461004
DOI: 10.1016/j.expneurol.2017.04.015

Genes

PER2
BMAL1

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