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Article

Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.

Neuroscience letters - 29 May 2018

Wu Meina, Zhou Fang, Cao Xiuli, Yang Junting, Bai Yu, Yan Xudong, Cao Jimin, Qi Jinshun

Abstract excerpt

Circadian rhythm disturbance (CRD) is one of the iconic manifestations in Alzheimer's disease (AD), a disease tightly associated with age, but the characteristics and gender difference of CRD occurred in AD have not been well demonstrated. Using 6-month-old triple transgenic AD mouse model (3xTg-AD) without obvious brain pathological changes, we demonstrated the gender difference of CRD at this age. We further...

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PMID: 29626648
DOI: 10.1016/j.neulet.2018.04.008

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