Article

Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of tau pathology

2025-06-09

Abstract excerpt

Tauopathies are a group of neurodegenerative disorders caused by the misfolded microtubule-associated protein tau (MAPT), leading to its abnormal accumulation and hyperphosphorylation, and resulting in neuronal dysfunction and death. Tauopathy patients also experience disruptions to circadian rhythms of behavior and sleep. The connection between tau pathology and circadian dysfunction is not well understood, espec...

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Literature Corpus work: bc8d6235-de76-5e44-9bfa-f9999ec65ad1
DOI: 10.1101/2025.06.06.655835

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