Article

Circadian modulation by time-restricted feeding restores brain transcription and slows amyloid deposition in a mouse model of Alzheimer’s disease

2022-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a tragic neurodegenerative disease affecting more than 5 million Americans. Circadian disruptions impact nearly all AD patients, with reversal of sleep/wake cycles and agitation in the evening being common disturbances that manifest early in disease. These alterations support a role for circadian dysfunction as a driver of AD, emphasizing a critical need to investigat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97cd2802-2f52-5d02-bb21-f22a0a133f37
DOI: 10.1101/2022.10.07.511346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circadian modulation by time-restricted feeding restores brain transcription and slows amyloid deposition in a mouse model of Alzheimer’s diseaseDOI 10.1101/2022.10.07.511346Read

Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventionsSemantic proximity Read

Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease modelSemantic proximity Read

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegenerationSemantic proximity Read

Disruption of circadian clocks promote progression of Alzheimer's disease in diabetic miceSemantic proximity Read

Evaluating Circadian Dysfunction in Mouse Models of Alzheimer’s Disease: Where Do We Stand?Semantic proximity Read

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s diseaseSemantic proximity Read

Aging ADNP syndrome mice exhibit mutation/sex-dependent disruption of motor behavior and circadian rhythmicity.Semantic proximity Read

Intermittent fasting mitigates cognitive deficits in Alzheimer’s disease via the gut-brain axisSemantic proximity Read

A novel brainstem pathway to the circadian system links Tau neurofibrillary pathology to sundowning-related circadian dysfunction and associated sex differences in the TAPP mouse model of Alzheimer’s diseaseSemantic proximity Read

Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL-F/NL-F Models of Alzheimer's Disease.Semantic proximity Read

Glial cells are involved in Day–Night protein dysregulation in the hippocampus of a mouse model of Alzheimer’s diseaseSemantic proximity Read

Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogrammingSemantic proximity Read