Article

The circadian system is affected by Alzheimer's disease independently from amyloid beta deposits

2026-08-28

Abstract excerpt

Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer's disease (AD), preceding cognitive symptoms like memory loss. The suprachiasmatic nucleus (SCN) governs biological rhythms and receives direct retinal input via melanopsin-expressing retinal ganglion cells (mRGCs) to synchronize with environmental light cycles. The anatomical and functional basis for circadian disruption i...

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Literature Corpus work: 0664281a-4181-5b26-bd49-e80bffed49f0
DOI: 10.64898/2026.08.25.744599

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