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Selective human tau protein expression in different clock circuits of the <i>Drosophila</i> brain disrupts different aspects of sleep and circadian rhythms

2020-12-14

Abstract excerpt

Circadian behavioural deficits, such as increased daytime naps and reduced night-time sleep, are common in Alzheimer’s disease and other tauopathies. But it has remained unclear whether these circadian abnormalities arise from tau pathology in either the master pacemaker or downstream neurons. Here we study this question by selectively expressing different human tau proteins in specific Drosophila brain circuits...

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Identifiers and source

Literature Corpus work
519ebf2e-6a7f-5b48-b7e6-fea01649af62
DOI
10.1101/2020.12.14.422675
Open publication

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Selective human tau protein expression in different clock circuits of the <i>Drosophila</i> brain disrupts different aspects of sleep and circadian rhythmsDOI 10.1101/2020.12.14.422675
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