Article

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signaling

2023-04-07

Abstract excerpt

Methotrexate is a well-known antineoplastic drug used to prevent cancer aggravation. Despite being a targeted therapeutic approach, its administration comes with the risk of cancer recurrence, plausibly through its proven off-target effect on focal adhesions. Since FA dynamics is dependent on force transmission through its constituent proteins, including talin, methotrexate might affect the mechanical activity of...

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Literature Corpus work: 07988423-ce56-538b-8bdb-ddb1a8859cd0
DOI: 10.1101/2023.04.07.535979

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