Article

ATP allosterically stabilizes Integrin-linked kinase for efficient force generation

2021-03-31

Abstract excerpt

Focal adhesions link the actomyosin cytoskeleton to the extracellular matrix regulating cell adhesion, shape, and migration. Adhesions are dynamically assembled and disassembled in response to extrinsic and intrinsic forces, but how the essential adhesion component intergrin-linked kinase (ILK) dynamically responds to mechanical force and what role ATP bound to this pseudokinase plays remains elusive. Here, we app...

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Literature Corpus work: 603ab83b-4639-5cf2-9be1-131b2088ff01
DOI: 10.1101/2021.03.30.437490

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