Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.

Science advances - 23 Aug 2024

Chanduri Manasa, Kumar Abhishek, Weiss Dar, Emuna Nir, Barsukov Igor, Shi Miusi, Tanaka Keiichiro, Wang Xinzhe, Datye Amit, Kanyo Jean, Collin Florine, Lam TuKiet, Schwarz Udo D, Bai Suxia, Nottoli Timothy, Goult Benjamin T, Humphrey Jay D, Schwartz Martin A

Abstract excerpt

Tissue mechanical properties are determined mainly by the extracellular matrix (ECM) and actively maintained by resident cells. Despite its broad importance to biology and medicine, tissue mechanical homeostasis remains poorly understood. To explore cell-mediated control of tissue stiffness, we developed mutations in the mechanosensitive protein talin 1 to alter cellular sensing of ECM. Mutation of a...

Topics

Talin
Animals
Homeostasis
Mice
Extracellular Matrix
Humans
Mechanotransduction, Cellular
Mutation
Actin-Related Protein 2-3 Complex
Aorta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Biomechanical Phenomena

Source

Open in PubMed Open full text

Identifiers

PMID: 39167642
DOI: 10.1126/sciadv.adi6286
PMCID: PMC11338229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.PMID 39167642Read ↗

Mechanobiology of myofibroblast adhesion in fibrotic cardiac diseaseSemantic proximity Read ↗

Cardiomyocyte mechanical memory is regulated through the talin interactome and DLC1 dependent regulation of RhoASemantic proximity Read ↗

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read ↗

Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling.Semantic proximity Read ↗

Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.Semantic proximity Read ↗

Matrix stiffness-induced transcriptome alterations and regulatory mechanisms revealed by RNA-seq in Endothelial cellsSemantic proximity Read ↗

Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and DifferentiationSemantic proximity Read ↗

Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vesselsSemantic proximity Read ↗

Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosisSemantic proximity Read ↗

Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECMSemantic proximity Read ↗

A genetic strategy for the dynamic and graded control of cell mechanics, motility, and matrix remodeling.Semantic proximity Read ↗

Mechanobiology and diseases of mechanotransductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.