Nanomechanical Phenotyping of Circulating Tumor Cells with Atomic Force Microscopy.

Abstract excerpt

Tumor cells shed into the bloodstream are exposed to significant mechanical forces that are distinct from the native environment of epithelial-like cells. The surviving circulating tumor cells (CTCs) respond to circulation conditions with a range of mechanical adaptations resulting in their "mechanical fitness." Multiparameter nanomechanical phenotyping with atomic force microscopy (AFM)-based force spectrometry...

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