Article

AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs

2024-11-15

Abstract excerpt

Cadherin-mediated adhesions are crucial mechanical and signaling hubs that connect cells within a tissue and probe the mechanics of the surrounding environment. They constitute a physical link between the actin cytoskeleton of neighboring cells, providing the mechanical coordination needed for morphogenetic processes, tissue homeostasis, collective migration, and regeneration. Disruptions in adhesion mechanisms ar...

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Literature Corpus work: 959802eb-889c-5e0d-a379-b9e77746f3bb
DOI: 10.1101/2024.11.14.623670

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