Article
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation.
Nucleus (Austin, Tex.) - 1 Jan 2015
Lanzicher Thomas, Martinelli Valentina, Long Carlin S, Del Favero Giorgia, Puzzi Luca, Borelli Massimo, Mestroni Luisa, Taylor Matthew R G, Sbaizero Orfeo
Abstract excerpt
Previous investigations suggested that lamin A/C gene (LMNA) mutations, which cause a variety of human diseases including muscular dystrophies and cardiomyopathies, alter the nuclear mechanical properties. We hypothesized that biomechanical changes may extend beyond the nucleus.
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