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A Generalizable Tension Sensor Platform for Mechanotherapeutic Discovery

2025-05-19

Abstract excerpt

Mechanical forces are critical regulators of cellular function, and their modulation represents a promising therapeutic strategy across a range of diseases, including cancer and fibrosis. DNA-based molecular tension sensors (MTSs) have emerged as powerful tools for detecting receptor-specific cellular forces but remain limited by susceptibility to nuclease degradation and constrained ligand compatibility. Here, we...

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Identifiers and source

Literature Corpus work
8442cb27-9fa9-5a71-9390-4a933afb8009
DOI
10.1101/2025.05.15.653325
Open publication

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A Generalizable Tension Sensor Platform for Mechanotherapeutic DiscoveryDOI 10.1101/2025.05.15.653325
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