Article

The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression

2017-06-06

Abstract excerpt

α-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial PD. A previous study showed that a variant of α-synuclein gene (SNCA), namely the 263bp allele of Rep1 was associated to faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the in...

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Literature Corpus work: 077d7c90-4d92-58c5-b36c-513354c9412c
DOI: 10.20944/preprints201706.0034.v1

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