Article
alpha-Synuclein and Parkinson disease susceptibility.
Neurology - 30 Oct 2007
Winkler S, Hagenah J, Lincoln S, Heckman M, Haugarvoll K, Lohmann-Hedrich K, Kostic V, Farrer M, Klein C
Abstract excerpt
BACKGROUND: Mutations in the alpha-synuclein (SNCA) gene have been shown to be responsible for a rare familial form of Parkinson disease (PD). Furthermore, polymorphic variants in multiple regions of the gene have been associated with susceptibility to idiopathic PD in different populations. OBJECTIVE: To evaluate and to confirm the role of SNCA variants in PD pathogenesis. METHODS: We included 667 subjects (397...
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