Article
Carriers of Parkinson's disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study.
Aging - 3 Feb 2025
Santhanakrishnan Aarthi, Tan Yi Jayne, Saffari Seyed Ehsan, Zhao Yi, Ng Ebonne Y L, Ng Samuel Y E, Chia Nicole S Y, Choi Xinyi, Heng Dede, Neo Shermyn, Xu Zheyu, Tay Kay Yaw, Au Wing Lok, Tan Eng-King, Tan Louis C S, Ng Adeline S L
Abstract excerpt
Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients...
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