Article
The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.
Neurogenetics - 1 Aug 2014
Lahut Suna, Vadasz David, Depboylu Candan, Ries Vincent, Krenzer Martina, Stiasny-Kolster Karin, Basak A Nazli, Oertel Wolfgang H, Auburger Georg
Abstract excerpt
Gain-of-function mutations of alpha-synuclein (SNCA) are known to trigger Parkinson's disease (PD) with striatal dopaminergic deficits and a reduction of spontaneous movements. The longest size variant (allele 2) of the complex microsatellite repeat Rep1 within the SNCA gene promoter is known to confer a PD risk. We now observed this Rep1 allele 2 to show significantly decreased frequency in restless legs...
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